منابع مشابه
Effects of Spray Drying and Spray Chilling on Ibuprofen Dissolution
The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...
متن کاملMechanistic Understanding of Spray Drying
Purpose Spray drying is a growing technology in the pharmaceutical industry with several enabling applications in modern drug delivery. Its understanding is still vastly empirical, mainly in what relates to the particle formation step. Consequently, the design spaces are typically defined through costly experiments and their statistical interpretation. The purpose of this study is to examine th...
متن کاملModeling of Particle Formation during Spray Drying
A mathematical model for the evaporation of a single droplet, subjected to convective drying in a spray dryer was developed to study the transient phenomena of particle formation. During the constant-rate drying period, the governing equations and boundary conditions were transformed into a form containing Peclet number, Pe, as the main controlling parameter. A numerical solution was developed ...
متن کاملModelling spray drying processes for dairy products
NIZO food research (The Netherlands) has been working for the food industry, the dairy industry in particular, for over 50 years. During the past 15 years NIZO food research has put a lot of effort into developing predictive computer models for the food industry. Nowadays the main challenges in the production of powders are the development of specialities (having a high added value) and the red...
متن کاملSpray-Drying to Get Spin-Crossover Materials
Spin-crossover (SCO) triazole-based coordination polymers can be synthesized by micelle techniques, which almost always lead to rod-shaped nanoparticles. In order to notably reach new morphologies, we explore here the potentiality of the spray-drying (SD) method to get SCO materials. Three SCO coordination polymers and a mononuclear complex are investigated. In all cases, the SD method obtains ...
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ژورنال
عنوان ژورنال: Revista do Instituto de Laticínios Cândido Tostes
سال: 2013
ISSN: 2238-6416
DOI: 10.5935/2238-6416.20130020